Genotype-associated clinical markers of atopic phenotype development in children

Atopic march (AM) occurs as the linear progression of atopic disorders (AtD) from dermatitis (AD) phenotype to its combinations with other AtD: allergic rhinitis/rhinoconjunctivitis (AR/ARC) and bronchial asthma (BA). Thymic stromal lymphopoietin (TSLP) plays an important role in AtD pathogenesis. Single nucleotide variant (SNV) rs11466749 TSLP gene during last decades showed controversial roles A/A, A/G G/G genotypes occurrence mono- polyorgan AM phenotypes children. Purpose - determine associations risks homozygous or heterozygous SNV Materials methods. The study involved 398 children aged 3 18 years old: 293 main group 105 control group. Patients suffered 6 different phenotypes: «AD», «AR\ARC», «BA», «AD+AR/ARC», «BA+AR/ARC», «AD+AR/ARC+BA»; patients gastrointestinal pathology. all cohorts were genotyped for genotype variants by polymerase chain reaction real time. Pearson’ contingency coefficient (rb), Pearson test (ꭕ2), Fisher’s exact test, odds ratio (OR) a 95% confidence interval (95% CI) used statistical processing obtained results. Results at p≤0.05 considered statistically significant. Results. A/A was significantly most frequent oligoorgan affection «AR/ARC» «BA+AR/ARC» «AD+AR/ARC+BA»: 66,2%, 65.3% 76.9% respectively (p<0.05). Heterozygous second significant frequent: 31.0% (p<0.05), 31.9% (p=0.05-0.1) «AD+AR/ARC+BA» 11.5% Genotype associated increased development specified rb=0.156, OR=1.92 CI: 1.03-3.58, p<0.05); rb=0.147, OR=1.84 1.0-3.42, rb=0.212, OR=3.27 1.22-8.80, p<0.05). reliably had protective effect on bespoke rb=0.148, OR=0.53 0.28-1.0, «BA+AR/ARC2 rb=0.138, OR=0.55 0.30-1.04, p=0.05-0.1); rb=0.280, OR=0.15 0.04-0.55, Conclusions. increases risk developing «AR/ARC», «AD+AR/ARC+BA», possesses their research carried out accordance principles Helsinki Declaration. protocol approved Local Ethics Committee participating institution. informed consent patient conducting studies. No conflict interests declared author.